Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037

Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Farnesyl pyrophosphate synthase, ... Authors: Park, J, Schilling, M.A, Berghuis, A.M. Deposit date: 2018-11-28 Release date: 2019-11-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS). J.Med.Chem., 62, 2019人类FPPS（Farnesyl pyrophosphate synthase，法尼基焦磷酸合酶）与变构抑制剂YF-02037复合物的晶体结构 描述符：1,2-乙二醇、氯离子、法尼基焦磷酸合酶等 作者：Park, J、Schilling, M.A、Berghuis, A.M 沉积日期：2018-11-28 发布日期：2019-11-06 最后修改日期：2023-10-11 实验方法：X射线衍射（分辨率2 Å） 引用文献：《人类法尼基焦磷酸合酶（hFPPS）α-氨基膦酸类变构抑制剂的手性驱动结合模式》，《药物化学杂志（J. Med. Chem.）》，2019年，第62卷