Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Missed Abortion

Abstract Objective Missed abortion occurs in ~ 15% of all clinical pregnancies. The pathogenesis is not clearly known. However, defective placentation resulting in maternal systemic inflammatory response is considered responsible for missed abortion. Platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) are increasingly cited parameters of inflammation in the literature. However, no study evaluated the PLR and NLR rates in missed abortions so far. The aim of the present study is to investigate whether complete blood count (CBC) inflammatory parameters such as NLR and PLR are increased in patients with missed abortion. Methods Medical records of 40 pregnant women whose gestation ended in missed abortion at between 6 and14 weeks of gestation and of 40 healthy pregnant women were collected and compared retrospectively. The groups were compared regarding hemoglobin, hematocrit, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), PLR and NLR. Results Platelet distribution width, NLR and PLR values were higher in the missed abortion group compared with the healthy pregnant women group (rates are p = 0.043; p = 0.038; and p = 0.010, respectively). Hematocrit, MPV, and lymphocyte values were found to be lower in the missed abortion group compared with the healthy pregnant women group (p = 0.027, p = 0.044 and p = 0.025, respectively). Conclusion The PDW, NLR and PLR values of the missed abortion group were reported high; and MPV values were reported low in the present study. These findings may help to speculate a defective placentation in the pathogenesis of missed abortion.

摘要：
研究背景与目的：稽留流产（missed abortion）约占所有临床妊娠的15%，其发病机制尚未完全明确。现有研究认为，胎盘形成缺陷引发母体全身炎症反应是稽留流产的致病诱因。血小板淋巴细胞比值（platelet lymphocyte ratio, PLR）与中性粒细胞淋巴细胞比值（neutrophil lymphocyte ratio, NLR）是近年来文献中日益受到关注的炎症指标，但截至目前尚无研究针对稽留流产患者的PLR与NLR水平展开评估。本研究旨在探讨稽留流产患者的血常规（complete blood count, CBC）相关炎症指标（如NLR与PLR）是否存在升高情况。

研究方法：本研究回顾性收集了6~14孕周确诊为稽留流产的40例妊娠妇女，以及40例健康妊娠妇女的病历资料并进行对比分析。对两组受试者的血红蛋白、血细胞比容、血小板计数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）、PLR及NLR水平进行比较。

研究结果：稽留流产组的PDW、NLR及PLR水平均高于健康妊娠组，差异具有统计学意义（分别对应p=0.043、p=0.038及p=0.010）；稽留流产组的血细胞比容、MPV及淋巴细胞计数水平则低于健康妊娠组，差异同样具有统计学意义（分别对应p=0.027、p=0.044及p=0.025）。

研究结论：本研究显示，稽留流产组的PDW、NLR及PLR水平升高，而MPV水平降低。上述研究结果可为推测稽留流产的发病机制与胎盘形成缺陷相关提供参考依据。