MELANOCORTIN RECEPTOR ACCESSORY PROTEIN 2-INDUCED ADRENOCORTICOTROPIC HORMONE RESPONSE OF HUMAN MELANOCORTIN 4 RECEPTOR

Human (h) and zebrafish (zf) melanocortin receptor 4 (MC4R) activation data.
Our data shows how both h and zfMC4R increase the sensitivity to the adrenocorticotropic hormone (ACTH) when interacting with the melanocortin receptor two accessory protein type 2 (MRAP2). Therefore, MC4R becomes an ACTH receptor in the presence of MRAP2 thus opening new gates to the stress effects mediated by ACTH. This MRAP2-induced ACTH sensitivity of MC4R is evolutionary conserved (zebrafish-human) thus suggesting a physiological role for the MC4R/MRAP2 interaction

本数据集包含人类（h）与斑马鱼（zf）黑皮质素4受体（melanocortin receptor 4, MC4R）的激活相关数据。研究数据显示，当与2型黑皮质素受体辅助蛋白2（melanocortin receptor two accessory protein type 2, MRAP2）相互作用时，hMC4R与zfMC4R均可提升对促肾上腺皮质激素（adrenocorticotropic hormone, ACTH）的敏感性。据此，在MRAP2存在的条件下，MC4R可转化为ACTH受体，从而为ACTH介导的应激效应研究开辟了新路径。这种由MRAP2诱导的MC4R对ACTH的敏感性在进化上具有保守性（斑马鱼-人类），由此提示MC4R与MRAP2的相互作用具备生理学功能意义。