BindingDB Entry 50047854: The"Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.

Small molecule binding data for protein Cysteinyl leukotriene receptor 1, Delta-type opioid receptor, Fibroblast growth factor receptor 1, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, HMG-CoA reductase, Hepatocyte growth factor receptor, Kappa-type opioid receptor, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, Macrophage-stimulating protein receptor, Mu-type opioid receptor, NT-3 growth factor receptor, Neurotrophic tyrosine kinase receptor, Neurotrophic tyrosine kinase receptor type 2, Platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, SRC, Serine/threonine-protein kinase PLK1, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase receptor FLT3, Tyrosine-protein kinase receptor UFO, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), and cAMP-specific 3',5'-cyclic phosphodiesterase 4B, Uniprot L7RSL3, P04629, P06239, P07949, P08581, P09619, P10721, P11362, P16234, P17948, P30530, P35372, P35916, P35968, P36888, P41143, P41145, P51639, P53350, Q02763, Q04912, Q07343, Q16288, Q16620, and Q2NNR5

本数据集包含针对下述多种蛋白的小分子结合数据：半胱氨酰白三烯受体1（Cysteinyl leukotriene receptor 1）、δ型阿片受体（Delta-type opioid receptor）、成纤维细胞生长因子受体1（Fibroblast growth factor receptor 1）、黏着斑激酶1/血管内皮生长因子受体3（Focal adhesion kinase 1/vascular endothelial growth factor receptor 3）、羟甲基戊二酰辅酶A还原酶（HMG-CoA reductase）、肝细胞生长因子受体、κ型阿片受体（Kappa-type opioid receptor）、驱动蛋白1重链/酪氨酸蛋白激酶受体RET（Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET）、巨噬细胞刺激蛋白受体、μ型阿片受体（Mu-type opioid receptor）、神经营养因子3生长因子受体（NT-3 growth factor receptor）、神经营养酪氨酸激酶受体（Neurotrophic tyrosine kinase receptor）、神经营养酪氨酸激酶受体2型（Neurotrophic tyrosine kinase receptor type 2）、血小板衍生生长因子受体（Platelet-derived growth factor receptor）、血小板衍生生长因子受体β（Platelet-derived growth factor receptor beta）、Src激酶（SRC）、丝氨酸/苏氨酸蛋白激酶PLK1（Serine/threonine-protein kinase PLK1）、酪氨酸蛋白激酶Kit（Tyrosine-protein kinase Kit (Kit)）、酪氨酸蛋白激酶受体FLT3（Tyrosine-protein kinase receptor FLT3）、酪氨酸蛋白激酶受体UFO（Tyrosine-protein kinase receptor UFO）、血管内皮生长因子受体（Vascular endothelial growth factor receptor）、血管内皮生长因子受体2（Vascular endothelial growth factor receptor 2）、血管内皮生长因子受体2与酪氨酸蛋白激酶TIE-2（KDR与TIE2）、cAMP特异性3',5'-环磷酸二酯酶4B（cAMP-specific 3',5'-cyclic phosphodiesterase 4B）；同时包含UniProt编号为L7RSL3、P04629、P06239、P07949、P08581、P09619、P10721、P11362、P16234、P17948、P30530、P35372、P35916、P35968、P36888、P41143、P41145、P51639、P53350、Q02763、Q04912、Q07343、Q16288、Q16620及Q2NNR5的蛋白相关数据。