CD4+ T cell Differentiation
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下载链接：
https://www.omicsdi.org/dataset/cellcollective/6678
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资源简介：
The model includes 38 components and 96 biochemical interactions that regulate the differentiation process of major T cell subtypes, i.e., Th1, Th2, Th17 and iTreg cells. Individual components of the model represent lineage-specifying transcription factors (Tbet, GATA3, RORt, and Foxp3), STAT proteins, cytokines, their receptors, and other signaling molecules. The extracellular environment is represented in the model by eight cytokines and a (generic) TCR ligand known to play a role in T cell differentiation. PMID: 22871178
本模型包含38个组分与96条生化相互作用，用于调控主要T细胞亚型的分化过程，涵盖Th1、Th2、Th17及诱导性调节性T细胞（iTreg）。模型中的各组分分别对应谱系特异性转录因子（包括Tbet、GATA3、RORt与Foxp3）、信号转导与转录激活因子（STAT，Signal Transducer and Activator of Transcription）蛋白、细胞因子、其受体及其他信号分子。模型的细胞外环境由8种细胞因子与一种公认参与T细胞分化调控的（通用型）T细胞受体（TCR，T cell receptor）配体所表征。PMID：22871178
创建时间：
2018-04-12
