Global small RNA profiling of murine hemophilic arthropathy

We utilized high throughput small RNA sequencing method to profile the molecular modulation in acute and chronic hemophilic arthropathy condition in murine model. The main goal of the study is to identify the dysregulated small RNAs in the pathophysiological condition of hemophilic arthropathy. Understanding the small RNA modulation may provide insights to identify biomarkers and develop new therapeutics.

本研究采用高通量小RNA测序技术，对小鼠模型中急性与慢性血友病性关节病状态下的分子调控模式进行表达谱分析。本研究的核心目标为鉴定血友病性关节病病理生理状态下失调的小RNA。阐明小RNA的调控机制，可为相关生物标志物的筛选及新型治疗策略的开发提供新思路。