Additional file 1: of Cytokine clearance with CytoSorb® during cardiac surgery: a pilot randomized controlled trial

Table S1. Baseline and peri-operative characteristics of patients included in the coagulation sub study. *There were no significant differences between the groups with regard to any pre-operative or intra-operative characteristics (all p values > 0.05) except for protamine/heparin ratio (p = 0.02). †Chronic kidney disease was defined by a creatinine clearance < 30 ml/min. ‡Chronic heart failure was defined by a left ventricular ejection fraction < 40%. CABG, coronary artery bypass grafting, IQR interquartile range, SAPS II simplified acute physiology score, SD standard deviation, ICU intensive care unit. Table S2. Outcomes of patients included in the coagulation sub study. Table S3. Minimal detection range of cytokines by the Luminex® Platform. Table S4. Haemoglobin, platelets and coagulation tests. To be considered, pre-operative values, had to be obtained within 24 h of the procedure. Post-operative values were obtained on ICU admission. Abbreviations: aPTT activated partial thromboplastin time, INR international normalized ratio. p value for the effect of group in ANOVA for repeated measures. Table S5. Detailed list of adverse events. Table S6. Cause of death. (RTF 370 kb)附表S1：凝血亚研究纳入患者的基线及围手术期特征。*注：两组间除鱼精蛋白/肝素比值（p=0.02）外，其余术前、术中特征均无统计学差异（所有p值>0.05）。†慢性肾脏病定义为肌酐清除率<30 ml/min。‡慢性心力衰竭定义为左心室射血分数<40%。缩写定义如下：冠状动脉旁路移植术（coronary artery bypass grafting, CABG）、四分位距（interquartile range, IQR）、简化急性生理学评分Ⅱ（simplified acute physiology score, SAPS II）、标准差（standard deviation, SD）、重症监护病房（intensive care unit, ICU）。 附表S2：凝血亚研究纳入患者的临床转归情况。 附表S3：Luminex®平台检测细胞因子的最低检测范围。 附表S4：血红蛋白、血小板及凝血功能检测指标。纳入分析的术前检测值需在手术操作前24小时内获取，术后检测值于患者入住重症监护病房时采集。缩写说明：活化部分凝血活酶时间（activated partial thromboplastin time, aPTT）、国际标准化比值（international normalized ratio, INR）。组间效应的p值采用重复测量方差分析（analysis of variance, ANOVA）计算。 附表S5：不良事件详细清单。 附表S6：死亡原因。（RTF格式，文件大小370 kb）