Expression analysis of T-ALL cell lines TALL-1, RPMI-8402, SUPT11 and P12-ICHIKAWA after treatment with NVS-ZP7-3. Expression analysis of T-ALL cell lines TALL-1, RPMI-8402, SUPT11 and P12-ICHIKAWA after treatment with NVS-ZP7-3

Identification of a NVS-ZP7-3 response signature in T-ALL cell lines to understand the transcriptional response in both Notch pathway active cell lines and Notch pathway inactive lines. Overall design: Four cell lines treated with DMSO control or NVS-ZP7-3 in triplicate for a total of 24 samples.

本研究旨在鉴定T细胞急性淋巴细胞白血病（T-ALL）细胞系中NVS-ZP7-3的应答特征，以阐明Notch通路活化与失活细胞系的转录应答情况。总体实验设计：选取4种细胞系，分别以二甲基亚砜（DMSO）对照与NVS-ZP7-3进行处理，每组设置三次生物学重复，最终共计24个样本。