Replication Data for: Input Mycobacterium tuberculosis data for Resistance Deep Learning Model

Mycobacterium tuberculosis genetic mutation data obtained via whole genome sequencing using Illumina. Illumina raw reads were processed with Stampy and Platypus based pipeline for variant calling. Mutations found are listed, assuming >40% purity and meeting Platypus Pass criteria. Mutations not found not listed. All isolates met quality criteria to confirm coverage of regions of interest. Also included is a separate file with the same ids linking the genotypic data above with in vitro culture based drug susceptibility testing for 10 drugs. Further description of the data and methods is available here: https://doi.org/10.1101/275628 (2019)

本数据集包含通过因美纳（Illumina）平台全基因组测序获得的结核分枝杆菌（Mycobacterium tuberculosis）遗传突变数据。研究采用基于Stampy与Platypus的分析流程，对原始测序读段进行变异检出处理。仅列出符合筛选条件的检出突变位点，该筛选前提为菌株纯度高于40%且满足Platypus过滤通过标准，未检出的突变位点不予罗列。所有菌株分离株均通过质量控制标准，可确保目标研究区域的测序覆盖度达标。本数据集还附带一份独立文件，其采用相同的样本ID将上述基因型数据与10种药物的体外培养药敏试验（drug susceptibility testing, DST）结果进行关联。有关该数据集及实验方法的详细说明可参见：https://doi.org/10.1101/275628（2019年）