Systematic discovery of Short Linear Motifs decodes calcineurin phosphatase signaling

This dataset is associated with the publication Wigington, C.P., Roy J. et. al., 2020. This manuscript is currently in press in Molecular Cell. In brief: Wigington, Roy et al. elucidate a signaling network for the Ca2+-activated phosphatase, calcineurin by systematically uncovering calcineurin-binding SLiMs throughout the human proteome. Using in vitro, in silico and in vivo methods, they discover multiple calcineurin substrates including Notch1 and nucleoporins, leading to the unexpected finding that calcineurin regulates nuclear transport.

本数据集关联Wigington、C.P.与Roy J.等人2020年发表的研究成果，该稿件目前已被《分子细胞（Molecular Cell）》接收待刊。简言之：Wigington与Roy等人通过系统性筛查人类蛋白质组中可结合钙调神经磷酸酶（calcineurin）的短线性基序（SLiMs），阐明了该钙激活磷酸酶的信号调控网络。研究团队借助体外、计算机模拟及体内实验方法，发现了包括Notch1与核孔蛋白在内的多种钙调神经磷酸酶底物，进而意外揭示出钙调神经磷酸酶可调控核运输过程。