Serum Uric Acid Levels and the Risk of Impaired Fasting Glucose: A Prospective Study in Adults of North China

ObjectiveTo prospectively investigate the association between serum uric acid (SUA) level and incidence of impaired fasting glucose (IFG) in adult Chinese. MethodsWe evaluated 13,328 women and 41,350 men without diabetes and IFG. The participants were classified into quintile according to baseline level of SUA. Data were analyzed to examine the association between SUA levels and the incidence of IFG. We used Cox regression models to estimate the relative risk of IFG after adjusting for known risk factors. ResultsFor men, the second quintile of SUA has the lowest cumulative incidence of IFG (29.9%); the fifth quintile of SUA has the highest cumulative incidence of IFG (35.6%). After corrected with Cox regression, the first quartile and the fourth quartile have higher cumulative incidence of IFG than the second quintile, with the HR of 1.11(1.05-1.17) and 1.07(1.01-1.13), respectively. For women, the first quartile of SUA has the lowest cumulative incidence of IFG (20.7%), while the fifth quintile of SUA has the highest cumulative incidence of IFG (30.0%). However, there is no significant difference in IFG between different quintile after adjusted with Cox regression. ConclusionsThe results of this prospective study suggest that there is a higher risk of developing IFG in association with low or high SUA concentrations for men. These relationships were independent of other known risk factors. There is no significant correlation in the risk of developing IFG in association with SUA concentrations for women. Analyses excluding participants with hypertension or with hyperlipidemia and analyses with participants stratified by age reached similar conclusion.研究目的：本研究旨在前瞻性探讨中国成年人血清尿酸（SUA）水平与空腹血糖受损（IFG）发病风险之间的关联。 研究方法：本研究纳入13328名无糖尿病及空腹血糖受损（IFG）病史的女性，以及41350名同条件的男性受试者。根据受试者基线血清尿酸（SUA）水平将其分为五个五分位组。通过数据分析探究SUA水平与IFG发病风险之间的关联，并采用Cox回归模型校正已知混杂危险因素后，估算IFG发生的相对风险（HR）。 研究结果：对于男性受试者而言，血清尿酸（SUA）水平处于第二五分位组者的IFG累积发病率最低（29.9%），处于第五五分位组者的IFG累积发病率最高（35.6%）。经Cox回归校正后，第一四分位组与第四四分位组的IFG累积发病率均高于第二五分位组，风险比（HR）分别为1.11（95%置信区间：1.05~1.17）与1.07（95%置信区间：1.01~1.13）。对于女性受试者而言，血清尿酸（SUA）水平处于第一四分位组者的IFG累积发病率最低（20.7%），而处于第五五分位组者的IFG累积发病率最高（30.0%）。但经Cox回归校正后，不同五分位组女性的IFG发病风险无显著差异。 研究结论：本前瞻性研究结果显示，男性受试者的IFG发病风险与血清尿酸（SUA）水平呈U型关联，即低或高SUA水平者的IFG发病风险更高，且该关联独立于其他已知混杂危险因素。而女性受试者的IFG发病风险与SUA水平之间未发现显著相关性。在剔除合并高血压或高脂血症受试者以及按年龄分层的亚组分析中，均得到了一致的研究结论。