Expression data from kidney biopsies of patients with chronic liver disease. Expression data from kidney biopsies of patients with chronic liver disease

Identification of increased complement component expression in the kidneys of patients with defined chronic liver disease etiology will allow future mechanistic studies of liver-associated renal injury. This study demonstrates the urgency for further investigation of renal function relative to inflammatory liver diseases. Overall design: Renal biopsies from patients with chronic liver disease underwent RNA extraction and hybridization on Affymetrix microarrays to obtain global transcriptional profiles for hypothesis driving experiments

明确病因的慢性肝病患者肾脏组织中补体成分表达上调的鉴定，可为后续开展肝脏相关性肾损伤的机制研究提供重要支撑。本研究凸显了针对炎症性肝病开展肾功能相关深入探究的紧迫性。实验设计概述：采集慢性肝病患者的肾脏活检组织，提取RNA后在Affymetrix微阵列芯片上完成杂交，以获取全局转录组谱，用于开展基于研究假说的相关实验。