Supplementary Material for: Necrosis of Pedunculated Lipofibroma by Nab-Paclitaxel

We present a rare phenomenon of a soft tumor hanging on the woman’s left upper arm that underwent necrosis from the distal aspect during chemotherapy for pancreatic cancer. The benign tumor, pedunculated lipofibroma, originally had normal color for 10 years and then became necrotic when she was treated with gemcitabine and nab-paclitaxel. Necrosis stopped in conjunction with chemotherapy cessation. Dermatologists must remember that nab-paclitaxel could develop necrosis of a skin tumor.

本研究报道一例罕见病例：一名女性在接受胰腺癌化疗期间，其左上臂悬挂的软组织肿瘤从远端部位开始发生坏死。该良性肿瘤为带蒂脂纤维瘤（pedunculated lipofibroma），10年来外观均正常，在接受吉西他滨（gemcitabine）与白蛋白结合型紫杉醇（nab-paclitaxel）联合治疗后出现坏死。随着化疗停止，肿瘤坏死情况随之终止。皮肤科医师需牢记：白蛋白结合型紫杉醇可引发皮肤肿瘤坏死。