In Vivo Transformation of NESp During Murine Bacteremia

The overall goal of this study was to ascertain regions of homologous recombination occurring in nonencapsulated pneumococcal strains when exposed to DNA from a highly virulent encapsulated pneumococcal strain during in vivo bacteremia. This study will help identify recombination hotspots that can result in novel pathogens produced by the selective pressure of vaccines.本研究的总体目标是探明：在体内菌血症 (in vivo bacteremia) 环境中，非荚膜肺炎链球菌菌株 (nonencapsulated pneumococcal strains) 接触一株高毒力荚膜肺炎链球菌菌株 (highly virulent encapsulated pneumococcal strain) 的DNA时，其所发生的同源重组 (homologous recombination) 区域。本研究将助力鉴定重组热点 (recombination hotspots)，此类热点可因疫苗的选择压力催生新型病原体。