HipSci HumanHT 12v4 Expression BeadChip analysis - monogenic diabetes

The HipSci project brings together diverse constituents in genomics, proteomics, cell biology and clinical genetics to create a UK national iPS cell resource and use it to carry out cellular genetic studies. In this sub-study we performed Expression analysis using the Illumina HumanHT -12 Expression BeadChip on iPS cells generated from skin biopsies or blood samples from rare disease patients diagnosed with monogenic diabetes.EGA study EGAS00001001277

HipSci项目汇聚了基因组学、蛋白质组学、细胞生物学与临床遗传学领域的多方研究力量，旨在构建英国国家诱导多能干细胞（induced pluripotent stem cell, iPS）资源库，并依托该资源开展细胞遗传学研究。本项子研究采用Illumina HumanHT-12表达微珠芯片（Illumina HumanHT-12 Expression BeadChip），对从确诊为单基因糖尿病的罕见病患者的皮肤活检样本或血液样本中诱导生成的iPS细胞开展了表达谱分析。相关研究的欧洲基因组-表型组档案（European Genome-phenome Archive, EGA）编号为EGAS00001001277。