Trichiconins A–C, Limonoids with New Carbon Skeletons from <i>Trichilia connaroides</i>

Three limonoids, trichiconin A (1) possessing a new carbon skeleton of a rearranged A,B-ring system and trichiconins B (2) and C (3) featuring an unprecedented A,B,D-seco skeleton, were isolated from the twigs of Trichilia connaroides. The carbon scaffold of trichiconin A is designated as trichiconane. Their structures with absolute stereochemistry were determined by spectroscopic data, X-ray crystallography, and CD analysis. Compounds 2 and 3 showed modest anti-HIV activities.从茸果鹧鸪花（Trichilia connaroides）的细枝中分离得到3个柠檬苦素类化合物（limonoids）：其中川楝尼定A（trichiconin A，1）具有重排A、B环体系的新型碳骨架，川楝尼定B（trichiconin B，2）与川楝尼定C（trichiconin C，3）则具备前所未有的A、B、D断裂骨架。川楝尼定A的碳骨架被正式命名为川楝尼定烷（trichiconane）。研究人员通过波谱数据、X射线晶体衍射（X-ray crystallography）以及圆二色谱（CD）分析，确定了这三种化合物的完整结构及其绝对立体化学构型。化合物2与3表现出中等强度的抗HIV活性。