Values in μM, Mean ± Standard Deviation (SD). One-way ANOVA was performed independently for each compound to determine differences of the mean between groups. Tukey’s multiple compared pairwise differ

NIAID Data Ecosystem40

MRPA-independent mechanisms of antimony resistance in Leishmania infantum

利什曼原虫耐药性

抗药性机制发现

The ABC transporter MRPA is one of the few key Sb resistance proteins described to date, whose role in detoxification has been thoroughly studied in Leishmania parasites. Nonetheless, its rapid amplif

NIAID Data Ecosystem30

Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of Trivalent Sodium Stibogluconate. Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of Trivalent Sodium Stibogluconate

利什曼原虫耐药性

转录组学分析

In the last decade the resistance to antimonials has become a serious problem due to the emergence of drug resistant strains. Therefore, understanding the mechanisms used by Leishmania parasites to su

NIAID Data Ecosystem40

Re sequencing of Leishmania infantum strains with different resistance to allopurinol

利什曼原虫耐药性

基因拷贝数变异

Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy number

NIAID Data Ecosystem40

LINF_270014100

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