A lactate-fatty acid loop mediating metabolic symbiosis between prostate tumors and osteoblasts drive metastatic bone colonization

Bone metastases (BoMs) are associated with a five-fold increased risk of mortality in patients with advanced prostate cancer (PCa). However, the current treatments offer only marginal improvements in survival and symptom management. In this study, we found that prostate tumors rewire their metabolism to adapt to the bone microenvironment by utilizing lactate as a net carbon source for fatty acid synthesis.

骨转移瘤（Bone metastases, BoMs）与晚期前列腺癌（prostate cancer, PCa）患者的死亡风险升高五倍显著相关。然而，当前的治疗方案仅能在生存延长与症状控制方面带来有限的改善。本研究发现，前列腺肿瘤可通过将乳酸作为脂肪酸合成的净碳源，重塑自身代谢模式以适应骨微环境。