Supplementary Materials for JAPPL-00332-2025

Figure S1. Flowchart of screening and randomization of ITP patients. Figure S2. Specific effects of platelet counts and age on sleep latency, sleep disturbances, use of sleep medication, and subjective sleep quality. Note: (a-b, d) At platelet counts below 50×109/L, higher scores for sleep latency, sleep disturbances, and subjective sleep quality are observed across all age groups. (c) For platelet counts below 50×109/L, individuals older than 30 show a higher distribution of sleep medication scores (due to the small sample size and infrequent use of sleep medication among patients, this may not be representative). Figure S3. Specific contributing factors to sleep disturbances include insufficient sleep. Figure S4. Serotonin levels in the blood circulation between healthy individuals and ITP patients. Note: Serotonin (5-HT) levels in ITP patients are significantly lower than in healthy individuals (P<0.001).

补充图S1 原发免疫性血小板减少症（ITP）患者的筛选与随机化流程图。补充图S2 血小板计数与年龄对睡眠潜伏期、睡眠障碍、睡眠药物使用及主观睡眠质量的特异性影响。注：(a-b、d) 当血小板计数低于50×10^9/L时，所有年龄组的睡眠潜伏期、睡眠障碍及主观睡眠质量评分均更高。(c) 当血小板计数低于50×10^9/L时，30岁以上人群的睡眠药物评分分布更高（由于患者样本量较小且睡眠药物使用频率较低，该结果可能不具有代表性）。补充图S3 睡眠障碍的具体影响因素包括睡眠不足。补充图S4 健康个体与ITP患者的血液循环5-羟色胺水平。注：ITP患者的5-羟色胺（Serotonin，5-HT）水平显著低于健康个体（P<0.001）。