Supplementary Material for: Scoping Review: Integration of the Major Mechanisms Underlying the Regulation of Arteriolar Tone

Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality worldwide. Arteriolar tone regulation plays a critical role in maintaining appropriate organ blood flow and perfusion distribution, which is vital for vascular and overall health. Impaired arteriolar function has been associated with the evolution and manifestation of various CVD conditions, emphasizing the importance of understanding arteriolar reactivity. This scoping review aims to explore the interplay between five major regulators of arteriolar tone - metabolism (adenosine), adrenergic control (norepinephrine), myogenic activation (intravascular pressure), perivascular oxygen tension, and intraluminal flow rates. Specifically, the aim was to address how arteriolar reactivity changes in the presence of other vasoactive stimuli and by what mechanisms. The review focused on animal studies that investigated the impact of combining two or more of these stimuli on arteriolar diameter. 848 articles were identified through MEDLINE and EMBASE database searches, and 38 studies were included in the final review. The results indicate that arteriolar reactivity is influenced by multiple factors, including competitive processes, structural limitations, and indirect interactions among stimuli. Additionally, the review identified a lack of research involving female animal models and limited insight into the interaction of molecular signaling pathways, which represent gaps in the literature.

心血管疾病（CVD）仍是全球范围内引发疾病负担与死亡的首要病因。动脉血管张力（arteriolar tone）调控在维持器官适宜血流量与灌注分布中发挥关键作用，这对血管健康与整体机体健康至关重要。动脉血管功能受损与多种心血管疾病的发生发展及临床表现密切相关，凸显了探究动脉血管反应性的重要意义。本范围综述（scoping review）旨在探究动脉血管张力的五大核心调控因子之间的相互作用，具体包括代谢（adenosine）、肾上腺素能调控（norepinephrine）、肌源性激活（intravascular pressure）、血管周围氧张力（perivascular oxygen tension）以及管腔内流速（intraluminal flow rates）。具体而言，本综述旨在阐明当存在其他血管活性刺激物（vasoactive stimuli）时动脉血管反应性的变化规律及其潜在作用机制。本综述聚焦于探究两种及以上上述刺激物联合应用对动脉血管直径影响的动物实验研究。通过MEDLINE与EMBASE数据库检索，本研究共识别出848篇相关文献，最终纳入38项研究进行最终综述分析。结果显示，动脉血管反应性受多重因素共同调控，包括刺激物间的竞争性过程、结构限制以及间接相互作用。此外，本综述还发现当前研究存在两处显著空白：一是缺乏针对雌性动物模型的相关研究，二是对分子信号通路相互作用的认知较为有限。