16S rRNA sequences of human fecal microbiota of mother-child pairs from Southern Brazil

This project contains sequences for 2 groups of mother-child pairs: i - HIV infected mothers and their HIV exposed but uninfected (HEU) children; ii - HIV uninfected mothers and their uninfected and unexposed children. The study goal was to evaluate alterations in the gut microbiota of HEU children, compared to unexposed and uninfected children. With the improvements in antiretroviral treatment and the development of programs to prevent the vertical transmission of HIV, the population of HEU children has been increasing in the past years. Although not infected by HIV, HEU children show several immune system alterations and a significantly higher number of infectious diseases, besides compromised growth and increased mortality rates. As the gut microbiota has an important impact in general host homeostasis and in the immune system development and modulation, we sought to evaluate if HEU children present alterations in the gut microbiota, and if these alterations could be related to the increased morbidity and the immune system disorders presented by them.

本数据集包含两组母婴对的肠道菌群测序序列：其一为人类免疫缺陷病毒（HIV）感染母亲及其HIV暴露但未感染（HIV Exposed but Uninfected，HEU）的子代；其二为HIV未感染母亲及其未暴露且未感染的子代。本研究的目标为对比HEU子代与未暴露未感染子代的肠道菌群，评估HEU子代肠道菌群的异常改变情况。随着抗逆转录病毒治疗技术的进步以及HIV母婴垂直传播预防项目的推广，近年来HEU子代的群体规模逐年扩大。尽管HEU子代并未感染HIV，但他们存在多项免疫系统功能异常，感染性疾病的发病率显著更高，同时还伴随生长发育受损与死亡率升高的问题。鉴于肠道菌群对宿主整体稳态、免疫系统发育与调控均具有关键作用，本研究旨在探究HEU子代是否存在肠道菌群失调，且此类菌群异常是否与该群体较高的发病率及免疫系统紊乱存在关联。