Gene expression changes upon drug withdrawal (Mel888 cell line)

In this study we investigate the mechanism of drug addiction Overall design: Drug was withdrawn from wt / MAPK1 KO / JUNB KO double drug resistant mel888 (DR Mel888) cells, and gene expression profiling was performed upon drug withdrawal本研究旨在探究药物成瘾的作用机制。实验设计：向野生型（wild type，缩写wt）、丝裂原活化蛋白激酶1敲除（MAPK1 KO）、JUNB敲除（JUNB KO）的双重耐药mel888（DR Mel888）细胞中撤除药物，并于药物撤除后开展基因表达谱分析。