Genetic Instrumental Variables for 211 Gut Microbiota Taxa, 102 Plasma Metabolites, and 3 Parkinson's Disease Phenotypes: SNP Summary Statistics from European Ancestry GWAS

Genetic Instrumental Variables for 211 Gut Microbiota Taxa, 102 Plasma Metabolites, and 3 Parkinson's Disease Phenotypes: SNP Summary Statistics from European Ancestry GWASData Description:This dataset provides comprehensive genetic instrumental variables (SNPs) and summary statistics for conducting Mendelian Randomization studies. It aims to investigate the potential causal relationships between gut microbiota, plasma metabolites, and Parkinson's Disease (PD) phenotypes.Data Content and Generation:The dataset comprises three core components:211 Gut Microbiota Taxa: Summary statistics were sourced from the MiBioGen consortium (18,340 individuals). Genomic coordinates were lifted over from GRCh37 to GRCh38.102 Plasma Metabolites: Genetic instruments were derived from a metabolome-wide association study of 8,299 individuals.3 Parkinson's Disease Phenotypes: GWAS summary statistics for PD and related phenotypes were obtained from the UK Biobank and the GWAS Catalogue (sample sizes up to 490,640). All data are from European-ancestry populations to minimize population stratification.Instrumental Variable Selection:Genetic instruments were selected with stringent criteria:Significance Thresholds: SNPs for microbiota (p < 1×10⁻⁵), metabolites (p < 5×10⁻⁶), and PD phenotypes (p < 5×10⁻⁸).This curated dataset provides a robust foundation for causal inference analysis in the gut microbiome-metabolite-PD axis.

针对211种肠道菌群类群、102种血浆代谢物及3种帕金森病表型的遗传工具变量：来自欧洲血统全基因组关联研究（Genome-Wide Association Study, GWAS）的单核苷酸多态性汇总统计数据
数据描述：本数据集提供了用于孟德尔随机化（Mendelian Randomization, MR）研究的全面遗传工具变量（单核苷酸多态性，Single Nucleotide Polymorphism, SNP）及汇总统计量，旨在探究肠道菌群、血浆代谢物与帕金森病表型之间潜在的因果关联。
数据内容与生成方式：数据集包含三大核心组成部分：
1. 211种肠道菌群类群：汇总统计量来源于MiBioGen联盟（样本量18340人），基因组坐标已从GRCh37版本映射至GRCh38版本。
2. 102种血浆代谢物：遗传工具变量源自一项纳入8299名受试者的代谢组全基因组关联研究（metabolome-wide association study, MWAS）。
3. 3种帕金森病表型：帕金森病及其相关表型的GWAS汇总统计量来源于英国生物银行（UK Biobank）与GWAS Catalog，最大样本量达490640。
所有数据均取自欧洲血统人群，以最小化人群分层带来的混杂偏倚。
工具变量筛选：
遗传工具变量的筛选采用严格标准：
显著性阈值：肠道菌群相关SNP的显著性阈值为p<1×10⁻⁵，代谢物相关SNP为p<5×10⁻⁶，帕金森病表型相关SNP为p<5×10⁻⁸。
本经精心筛选整理的数据集为肠道菌群-代谢物-帕金森病轴的因果推断分析提供了稳健的研究基础。