Life Course Adiposity and Non-alcoholic fatty liver disease: A Mendelian Randomization Study

Birthweight, childhood, and adult BMI have been indicated associated with the NAFLD, However, current studies have been influenced by confounding factors, and the independent role of these weight characteristics in NAFLD remains controversial.Therefore, it is necessary to use genetic methods to evaluate the genetic associations of birthweight, childhood and adult body mass index (BMI) on the NAFLD, and to determine whether birth weight and childhood obesity directly affects the risk of NAFLD independently of adult obesity.

出生体重、儿童期体质量指数与成年期体质量指数已被证实与非酒精性脂肪性肝病（NAFLD）相关。然而，现有研究均受混杂因素干扰，上述体重特征在非酒精性脂肪性肝病发生中的独立作用仍存在争议。因此，有必要采用遗传学方法评估出生体重、儿童期体质量指数及成年期体质量指数与非酒精性脂肪性肝病的遗传关联，并明确出生体重与儿童期肥胖是否可独立于成年肥胖，直接影响非酒精性脂肪性肝病的发病风险。