Data from: Validation of NINDS-VCI neuropsychology protocols for vascular cognitive impairment in Taiwan

Objective: To validate the three time-difference neuropsychological
protocols developed by the National Institute of Health/National Institute
of Neurological Disorders and Stroke (NINDS) and the Canadian Stroke
Network for assessment of vascular cognitive impairment (VCI) in
Mandarin-speaking subjects and to investigate the clinical application of
the shortest form. Methods: Patients aged 50 years or older who had a
stroke were invited to participate in the study. Clinical diagnosis of VCI
was made. The NINDS-VCI Neuropsychology Protocols, 60-, 30-, and two
5-minute protocols, were administered. The criteria validities of the
cognitive protocols against the diagnoses of stroke and VCI were
determined via Receiver Operating Characteristic (ROC) analysis. The
optimal cut-off point for the 5-minute protocols total score was estimated
for clinical use in screening. Results: Eighty-three patients and 53
controls were recruited during the study period. Patients with stroke
performed more poorly than the control group in the three
neuropsychological protocols. Forty-two patients with stroke were
diagnosed with VCI. VCI was used as the standard to estimate the criteria
validities. The area under the ROC curve was 0.78, 0.80, 0.75, and 0.73
for the 60-, 30-, 5-mintue protocol-A and 5-minute protocol-B,
respectively. Conclusion: These modified neuropsychological protocols can
be used as valid instruments when performing comprehensive cognitive
assessment or for screening of VCI in Taiwan.

研究目的：验证由美国国立卫生研究院/国立神经疾病与卒中研究所（National Institute of Health/National Institute of Neurological Disorders and Stroke, NINDS）与加拿大卒中网络开发的三种不同时长梯度的神经心理学评估方案，用于台湾地区普通话使用者的血管性认知障碍（vascular cognitive impairment, VCI）评估，并探讨最短时长方案的临床应用价值。研究方法：招募年龄50岁及以上的卒中患者参与本研究，对受试者完成血管性认知障碍的临床诊断。施测NINDS-VCI神经心理学方案，涵盖60分钟版、30分钟版及两个5分钟版评估方案。以卒中与VCI诊断为效标，通过受试者工作特征（Receiver Operating Characteristic, ROC）分析评估上述认知评估方案的效标效度，并针对5分钟版方案的总分估算适用于临床筛查的最佳截断值。研究结果：本研究周期内共纳入83例卒中患者与53例对照受试者。卒中患者在三项神经心理学评估方案中的表现均劣于对照组，其中42例卒中患者被确诊为VCI。以VCI诊断作为效标开展效度分析，60分钟版、30分钟版、5分钟版方案A及5分钟版方案B的ROC曲线下面积分别为0.78、0.80、0.75与0.73。研究结论：上述经改良的神经心理学评估方案，可作为针对台湾地区普通话人群的全面认知评估工具，或用于血管性认知障碍的临床筛查。