3D cyto- and receptor architectonic map of macaque somatosensory area PRm (v1.0)

A multimodal analysis of the macaque somatosensory cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This project involved a quantitative and statistically testable approach to the analysis of cyto-/myeloarchitecture in the macaque monkey somatosensory cortex, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 14 different neurotransmitter receptors. The borders of the identified areas were traced onto the macaque stereotaxic space provided by the MEBRAINS and Yerkes 19 templates.

We provide here for the first time a map of area PRm of the macaque monkey brain integrating cyto-, myelo- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates, and provides crucial data for modeling approaches with realistic synaptic dynamics.

本研究针对猕猴躯体感觉皮层开展多模态分析，旨在构建整合既往已发表图谱并调和其间差异的三维图谱。本项目采用定量且可经统计学检验的分析方法，对猕猴躯体感觉皮层的细胞构筑与髓鞘构筑进行解析，并结合体外定量受体放射自显影技术，分析14种不同神经递质受体的区域与层状分布模式。研究中确定的脑区边界被标注至由MEBRAINS与Yerkes 19模板提供的猕猴立体定位空间中。

本研究首次提供了猕猴大脑PRm脑区的图谱，该图谱整合了细胞构筑、髓鞘构筑与受体构筑特征，并适配立体定位空间。该图谱可为非人类灵长类动物的功能实验分析提供宝贵资源，同时为基于真实突触动力学的建模研究提供关键数据。