Cefiderocol Resistance in Carbapenem-Resistant Acinetobacter baumannii

Cefiderocol (CFDC), is a promising antimicrobial agent against most gram-negative bacteria. However, there was a significant variation of the CFDC resistance for carbapenem-resistant Acinetobacter baumannii (CR-AB). To explore potential mechanisms of resistance to CFDC, genomes and expression information of CR-AB isolates from patients in Beijing were explored.

头孢地尔（Cefiderocol，CFDC）是一种针对多数革兰氏阴性菌的极具潜力的抗菌药物。然而，耐碳青霉烯类鲍曼不动杆菌（carbapenem-resistant Acinetobacter baumannii，简称CR-AB）对头孢地尔的耐药性存在显著差异。为探究该菌对头孢地尔产生耐药性的潜在机制，本研究针对北京地区患者分离的CR-AB菌株的基因组与表达信息展开了分析。