Data for Prefrontal-hippocampal functional connectivity encodes recognition memory and is impaired in intellectual disability

This dataset contains electrophysiological recordings from euploid mice (EU) and the trisomic (TS) Ts65Dn mouse model of Down syndrome associated with the paper Alemany-González et al. PNAS (2020). The files are in .mat format. Each file includes 12 channels: 3 channels with data recorded from the medial prefrontal cortex (PFC), 3 channels from the CA1 area of the hippocampus (HPC), 3 reference electrodes with no neural activity (REF1 in corpus callosum, REF2 and REF3 in lateral ventricles) and the 3 channels of the accelerometer (x, y, z axis). The names of the files are organized as follows:

genotype_mousenumber_brainstate (for example, TS_01_QUIET).

The data is organized in three main folders that correspond to the three brain states investigated in the study:

- Quiet wakefulness
- Natural sleep (REM and NREM)
- The novel object recognition task
o Familiarization phase
o 24-hour memory test
- PDF document with detailed description of the dataset

In addition, we include data recorded during baseline conditions and after one month of oral treatment with epigallocatequin-3-gallate (EGCG) for the three brain states in trisomic mice only (TS_mousenumber_brainstate_EGCG). There are two additional mice that only received water and are labeled as WAT instead of EGCG. Finally, we also provide data of single-unit spike sorting in .nex format in euploid and trisomic mice for the quiet wakefulness condition. All the results and statistical analyses of the study are summarized in Supporting Tables S2-S4 of the main manuscript.

本数据集包含整倍体（euploid, EU）小鼠与唐氏综合征三体模型Ts65Dn（trisomic, TS）小鼠的电生理记录数据，关联论文为Alemany-González等人发表于《美国国家科学院院刊》（PNAS, 2020）的研究。所有文件均采用.mat格式存储。每份文件包含12个通道：3个记录于内侧前额叶皮层（medial prefrontal cortex, PFC）的通道、3个记录于海马CA1区（CA1 area of the hippocampus, HPC）的通道、3个无神经活动的参考电极（参考电极1置于胼胝体，参考电极2与3置于侧脑室），以及3个对应x、y、z轴的加速度计通道。
文件名命名规则如下：基因型_小鼠编号_脑状态（例如TS_01_QUIET）。
数据分为三个主文件夹，对应本研究考察的三种脑状态：
- 安静觉醒状态
- 自然睡眠（快速眼动睡眠REM与非快速眼动睡眠NREM）
- 新物体识别任务，其下包含两个子阶段：
o 熟悉阶段
o 24小时记忆测试
此外，本数据集还附带一份详细阐述数据集细节的PDF文档。
除此之外，本数据集还包含仅针对三体模型小鼠的、在基线条件下以及口服表没食子儿茶素没食子酸酯（epigallocatequin-3-gallate, EGCG）干预一个月后的三种脑状态数据，其文件命名规则为TS_小鼠编号_脑状态_EGCG。另有2只仅饮用清水的小鼠，其样本标记为WAT以替代EGCG。最后，我们还提供了安静觉醒状态下整倍体与三体模型小鼠的单单元锋电位分选数据，格式为.nex。本研究的全部结果与统计分析已总结于主论文的补充表S2-S4中。