Fertility Does not Quarantine: Coronavirus Disease 2019 Pandemic Impacts on in Vitro Fertilization Clinical Pregnancy Rates

Abstract Objective To understand the impact of the coronavirus disease 2019 pandemic on in vitro fertilization (IVF) clinical pregnancy rates and analyze factors that may have influenced their outcome. Methods This was a retrospective observational study conducted at a tertiary-care Brazilian fertility center. All fresh IVF and embryo warming cycles performed from March 11 to December 31, 2018–2021 were analyzed, and their data were used to calculate fertilization, embryo cleavage, cycle cancellation, embryo transfer (ET), and clinical pregnancy rates. Statistical tests were used to evaluate the alterations found. Logistic regression models were used to explore the association of the categorical variables with the observed clinical pregnancy rates. Data from 2018 and 2019 (prepandemic) and 2020 and 2021 (pandemic) were grouped. Results A total of 756 cycles were analyzed (n = 360 prepandemic and n = 396 pandemic). The age group of the patients, fertilization rates, and cleavage rates did not have significant differences (p > 0.05). There was a reduction in the percentage of fresh IVF and an increase in embryo warming cycles (p = 0.005) during the pandemic. There was also an increase in fresh cycle cancellations (p

摘要 目的：旨在明确新型冠状病毒肺炎（coronavirus disease 2019）大流行对体外受精-胚胎移植（in vitro fertilization, IVF）临床妊娠率的影响，并分析可能影响其结局的相关因素。方法：本研究为一项在巴西三级医疗生殖中心开展的回顾性观察研究。纳入2018—2021年3月11日至12月31日期间实施的全部新鲜体外受精周期与胚胎解冻复苏周期，通过收集相关数据计算受精率、胚胎卵裂率、周期取消率、胚胎移植（embryo transfer, ET）率及临床妊娠率，并采用统计学检验评估观察到的变化。同时构建逻辑回归模型，探究分类变量与观测到的临床妊娠率之间的关联。将2018、2019年（大流行前）与2020、2021年（大流行期间）的数据分别进行分组。结果：本研究共纳入756个周期（大流行前组360个，大流行组396个）。患者年龄分布、受精率及卵裂率均无显著性差异（p > 0.05）。大流行期间，新鲜体外受精周期占比有所下降，而胚胎解冻复苏周期占比则出现上升（p = 0.005）；同时新鲜周期取消率亦有所升高（p