Neutrophil-lymphocyte ratio in catatonia

Abstract Background There is growing evidence of subclinical inflammation in mental disorders. Objective The aim of this study was to investigate frequency of symptoms of catatonia and the newly diagnosed subclinical inflammatory markers which are neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), monocyte/lymphocyte (MLR) ratios in catatonia patients due to mental disorders. Methods: Patients who were admitted to psychiatry clinic with the diagnosis of catatonia according to DSM 5 in the last two years and equal number of control group were included in this retrospective study. Univariate analysis of covariance controlled for possible confounders was used to compare NLR, PLR, MLR ratios between patients and the control group. Results A total of 34 catatonia patients and 34 healthy controls were included in the study. Patients’ mean age was 30.88 + 13.4. NLR value was significantly higher in the patient group than control group. There was no significant difference between the patients and control group according to PLR, MLR values. Discussion The presence of subclinical inflammation in catatonic syndrome due to mental disorders should be considered. Subclinical inflammation that was observed in numerous mental disorders continues in catatonia due to mental disorders. Large-scale studies are needed to determine the role of inflammation in catatonia.

【摘要】背景：越来越多的研究证据表明，精神障碍患者存在亚临床炎症反应。
目的：本研究旨在探讨精神障碍相关性紧张症患者的紧张症症状发生频率，以及该类患者中新检测的亚临床炎症标志物——中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）及单核细胞与淋巴细胞比值（MLR）的水平。
方法：本研究为回顾性研究，纳入近2年内以符合《精神障碍诊断与统计手册（第五版）》（DSM-5）紧张症诊断标准收治于精神科的患者，以及与患者数量匹配的对照组人群。采用控制潜在混杂因素的单因素协方差分析，对比患者组与对照组的NLR、PLR及MLR水平。
结果：本研究共纳入34例紧张症患者与34例健康对照者。患者的平均年龄为30.88±13.4岁。患者组的NLR水平显著高于对照组；而两组间PLR、MLR水平无显著差异。
讨论：应考虑精神障碍相关性紧张症综合征存在亚临床炎症的可能。既往在多种精神障碍中观察到的亚临床炎症现象，在精神障碍相关性紧张症中同样存在。未来需开展大样本研究，以明确炎症在紧张症发病机制中的作用。