Structural Biology at EMBL Grenoble, IBS-CIBB and IAB

The proposals covers a broad range of structural biology projects related to pathogen biology, host-pathogen interactions, RNA biology and structure-based drug development that are carried out by PIs at EMBL Grenoble, IBS-CIBB and IAB. The proposers have long-standing experience in the use, as well as the development of beam lines for macromolecular crystallography and have participated in successive BAG applications over the years, mostly at the ESRF but also at other synchrotrons (e.g. Soleil, Petra III, Diamond, SLS).

本提案涵盖了由欧洲分子生物学实验室格勒诺布尔分部（EMBL Grenoble）、IBS-CIBB及IAB的首席研究员（Principal Investigator，PI）开展的一系列结构生物学项目，研究方向涉及病原生物学、宿主-病原体相互作用、RNA生物学以及基于结构的药物研发领域。提案方长期拥有大分子晶体学光束线的使用与开发经验，且多年来多次参与历届BAG申请，相关申请主要依托欧洲同步辐射光源（ESRF），同时也涉及其他同步辐射装置，例如Soleil、PETRA III、Diamond及SLS。