DataSheet1_Application of tight membrane extraction for amines separation.docx

Chiral amines are very valued constituents of many important pharmaceutical compounds and their intermediates. However, the production of a chiral amine encounters some challenges, like the use of harsh conditions and the unfavorable thermodynamic equilibrium. In this research the possibilities of tight membrane extraction (ME) for amines separation has been investigated to improve the reaction equilibrium. A specific transaminase reaction was selected for the study in which product amine 1-methyl-3-phenylpropylamine (MPPA) or methyl benzylamine (MBA) needs to be separated from the donor amine isopropylamine (IPA). Tight ME is an innovative separation process in which the membrane is not only an interface, but also a way to add extra selectivity to the process. In the present work, we thoroughly discuss the main factors influencing this novel technique by evaluating the extraction efficiency and extraction rates for the different amines. Then we also determine the optimal parameters for the selected reaction. Supported liquid membrane extraction (SLM), as well as pressure driven filtration, more specifically, nanofiltration (NF), were also studied as benchmark technologies, showing that tight ME has a greater advantage over the two in this specific case, due to the extra affinity factor offered by the membrane. The selectivity of MPPA/IPA in tight ME for the optimized parameters was significantly higher than for SLM and NF.

手性胺（chiral amines）是诸多关键医药化合物及其中间体的高价值组成成分。然而手性胺的生产过程面临诸多挑战，例如严苛的反应条件以及不利的热力学平衡限制。本研究针对胺类分离的紧凑型膜萃取（tight membrane extraction, ME）技术可行性展开探究，以期改善反应热力学平衡。本研究选取特定的转氨酶催化反应作为研究对象，该反应的产物胺为1-甲基-3-苯基丙胺（MPPA）或甲基苄胺（MBA），需从供体胺异丙胺（IPA）中分离得到。紧凑型膜萃取是一种创新性分离工艺，其膜组件不仅作为传质界面，更为该过程提供了额外的选择性调控途径。本研究通过评估不同胺类的萃取效率与萃取速率，系统探讨了影响该新型技术的核心影响因素，并确定了目标反应的最优工艺参数。本研究同时选取支撑液膜萃取（SLM）与压力驱动过滤技术（具体为纳滤（NF））作为对照基准技术，实验结果表明，得益于膜所提供的额外亲和作用，紧凑型膜萃取在该特定场景下相较于这两种基准技术具备更显著的优势。在优化参数条件下，紧凑型膜萃取体系中MPPA/IPA的分离选择性显著高于支撑液膜萃取与纳滤体系。