Impact of formulated GSNO at 30 mg/kg on MAP (panel A), HR (panel B) and PAP (panel C).

Each animal (n = 7) received all the treatments (Implants: 31.9 ± 0.5; Microparticles 30.9 ± 0.6 mg/kg). Day-night cycles are marked in days (D1, D2 and D3) and nights (N1, N2) periods. For more clarity, after the first hour, only one point for each hour was represented. *: p vs. PBS (one-way ANOVA; post-hoc Bonferroni test).每只动物（n=7）均接受全部处理方案（植入物组：31.9 ± 0.5；微粒组：30.9 ± 0.6 mg/kg）。昼夜周期以日间（D1、D2、D3）及夜间（N1、N2）时段标记。为使结果更清晰，首小时后仅以每小时一个数据点进行展示。*：与磷酸盐缓冲液（PBS）组比较的P值（单因素方差分析（one-way ANOVA）；Bonferroni事后检验）。