Total Synthesis of Tedarene A

Tedarene A is a macrocyclic diaryl ether heptanoid isolated from the marine sponge Tedania ignis showing an inhibitory effect against nitric oxide production. The first total synthesis of tedarene A was achieved starting from the commercially available 3-(4-methoxyphenyl)­propan-1-ol in nine steps and 15.3% overall yield. The synthetic sequence featured an E,Z-dienic bond introduction and a macrocyclization under Ullman conditions. During the synthesis, the E,E-isomer of tedarene A was also obtained and fully characterized.特达瑞宁A（Tedarene A）是一种从海洋海绵Tedania ignis中分离得到的大环二芳基醚庚烷类化合物，对一氧化氮生成具有抑制作用。首例针对特达瑞宁A的全合成以市售的3-(4-甲氧基苯基)丙-1-醇为起始原料，经9步反应完成，总产率达15.3%。该合成路线的核心特征为构建E,Z-二烯键，并在Ullman反应条件下完成大环化反应。在合成过程中，同时得到了特达瑞宁A的E,E-异构体，并对其进行了充分表征。