Thiourea–I₂ as Lewis Base–Lewis Acid Cooperative Catalysts for Iodochlorination of Alkene with In Situ-Generated I–Cl

Thiourea–I2 as Lewis base–Lewis acid cooperative catalysts are developed for the iodochlorination of alkenes with in situ-generated iodine monochloride (I–Cl). The Lewis base–Lewis acid cooperative system is sufficient to generate I–Cl from I2 with a chlorinating reagent at low temperature. Based on the solid-state structure of the active species, thiourea–I2 cooperatively captures I–Cl. By taking advantage of I–Cl generation and the control of I–Cl at low temperature, the thiourea–I2 cooperative system suppresses side reactions that arise from highly reactive free I–Cl.本研究开发了硫脲-碘单质（Thiourea–I2）作为路易斯碱-路易斯酸协同催化剂，用于以原位生成的一氯化碘（I–Cl）为反应物的烯烃碘氯化反应。该路易斯碱-路易斯酸协同体系可在低温下由碘单质与氯化试剂原位生成一氯化碘。基于活性物种的固态结构，硫脲-碘单质可协同捕获一氯化碘。借助低温下的一氯化碘生成与精准调控，该硫脲-碘单质协同体系可抑制由高活性游离态一氯化碘引发的副反应。