EGFR and EGFRvIII coopt host defense pathways, promoting progression in glioblastoma

To investigate the function of TLR2 in EGFR and EGFRvIII co-expressing glioblastoma cells, we knocked out TLR2 by CRISPR. We then performed gene expression profiling analysis using data obtained from RNA-seq of the cells.

为探究Toll样受体2（TLR2）在共表达表皮生长因子受体（EGFR）与表皮生长因子受体变体III（EGFRvIII）的胶质母细胞瘤细胞中的功能，我们通过CRISPR技术敲除了TLR2。随后，我们利用细胞的RNA测序（RNA-seq）数据开展基因表达谱分析。