Supplementary Material for: Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase

Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal melanoma with lipid production and expression of the enzyme HMG-CoA reductase. This case highlights an unusual UM tumour phenotype with a high-risk molecular metastatic profile and discusses tumour lipogenesis and activation of the mevalonate pathway as a potential therapeutic target in managing lipidised ciliochoroidal UM.

葡萄膜黑色素瘤（Uveal melanoma, UM）是成人最常见的原发性眼内恶性肿瘤。目前已发表的关于UM脂质生成的研究数据较为匮乏。本研究报道了1例伴脂质生成且表达羟甲基戊二酰辅酶A还原酶（HMG-CoA reductase）的睫状体脉络膜黑色素瘤的临床、组织病理学、免疫组织化学及分子生物学特征。该病例呈现出一类携带高风险分子转移表型的罕见UM肿瘤表型，并探讨了肿瘤脂质生成与甲羟戊酸途径激活作为脂质化睫状体脉络膜UM潜在治疗靶点的可行性。