DC3: Deconvolution and coupled clustering from bulk and single cell genomics data

HiChIP data generated for the retinoic acid-induced mESC differentiation at day 4. We introduce DC3 (for De-Convolution and Coupled-Clustering) as a method for the joint analysis of bulk HiChIP, scRNA-seq and scATAC-seq data from the same heterogeneous cell population.

本数据集包含视黄酸诱导的小鼠胚胎干细胞（mouse embryonic stem cell, mESC）在分化第4天时产生的HiChIP数据。我们提出DC3（De-Convolution and Coupled-Clustering，即去卷积与耦合聚类）方法，用于对来自同一异质性细胞群体的批量HiChIP、单细胞RNA测序（scRNA-seq）及单细胞ATAC测序（scATAC-seq）数据进行联合分析。