EGAS00001001182-sc-20160622 - samples

Given the central importance of Africa to studies of human origins, genetic diversity and disease susceptibility, large-scale and representative characterisation of genetic diversity in Africa is needed. Analyses of ancient DNA from Africa would complement sequencing of modern African populations and provide unique opportunities to transform our understanding of the pre-history of the region. This approach would greatly refine our understanding of population structure and gene flow in Africa and globally, including genetic signatures of ancient admixture. This low coverage sequencing experiment will allow us to test and refine our pipeline for ancient DNA sequencing.

This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/EGA dataset EGAD00001002211

鉴于非洲在人类起源、遗传多样性与疾病易感性研究中的核心地位，亟需对非洲的遗传多样性开展大规模且具代表性的表征分析。对非洲古DNA（ancient DNA）的分析可作为现代非洲人群基因组测序研究的重要补充，为革新我们对该区域史前史的认知提供独特契机。该研究路径将极大地深化我们对非洲乃至全球的人群结构与基因流的认知，其中涵盖古代混血事件的遗传特征标记。本次低覆盖度测序实验将助力我们测试并优化古DNA测序的生物信息分析流程。

本数据集属于预发布版本。若需了解威康桑格研究所（Wellcome Trust Sanger Institute）共享的预发布数据的规范使用要求（含各类出版暂缓细则），请访问 http://www.sanger.ac.uk/datasharing/ 查阅EGA数据集EGAD00001002211的相关说明。