Alu-mediated recombination rates and genetic analyses of candidate suppressors of Alu mediated recombination.

aUnreported heterozygous mutations within each gene screened for in women with early breast and/or ovarian cancer and with BRCA1 mutations.bNumber of sporadic breast tumors with loss of heterozygosity (LOH) of markers within or near each gene.cUnreported heterozygous mutations within each gene screened for in Ashkenazi Jewish families with breast cancer but without mutations in the known breast cancer genes.dUnreported heterozygous mutations within PIF1 in a series of 400 additional high-risk breast cancer probands with no mutations in the known breast cancer genes.

a. 早发性乳腺癌和/或卵巢癌且携带BRCA1突变的女性受试者中，所筛查的各基因内未被报道过的杂合突变。
b. 各基因内部或邻近区域标记物发生杂合性缺失（loss of heterozygosity, LOH）的散发性乳腺肿瘤例数。
c. 罹患乳腺癌但已知乳腺癌易感基因无突变的德系犹太人家系中，所筛查的各基因内未被报道过的杂合突变。
d. 在400余例额外的已知乳腺癌易感基因无突变的高风险乳腺癌先证者队列中，PIF1基因内未被报道过的杂合突变。