Prevalence of carbapenemase in Enterobacteriaceae with decreased susceptibility to carbapenems isolated in a tertiary referral hospital

ABSTRACT Infections caused by carbapenem-resistant Enterobacteriaceae are a serious public health issue. This work aims to analyze the resistance mechanisms related to Enterobacteriaceae with decreased susceptibility to carbapenems isolated at the Hospital Júlia Kubitschek (HJK) of the Minas Gerais State Founding Hospital [Fundação Hospitalar do Estado de Minas Gerais (FHEMIG)], Brazil. Seventy-one strains with reduced susceptibility to carbapenems were found, and 45/71 (63.4%) were Klebsiella pneumoniae carbapenems (KPC) producers.

摘要：耐碳青霉烯类肠杆菌科（carbapenem-resistant Enterobacteriaceae）感染是一类严重的公共卫生问题。本研究旨在分析从巴西米纳斯吉拉斯州医院基金会（Fundação Hospitalar do Estado de Minas Gerais, FHEMIG）附属朱莉亚·库比契克医院（Hospital Júlia Kubitschek, HJK）分离的、对碳青霉烯类抗菌药物敏感性降低的肠杆菌科菌株的耐药机制。本研究共检出71株对碳青霉烯类抗菌药物敏感性降低的菌株，其中45/71（63.4%）为产肺炎克雷伯菌碳青霉烯酶（Klebsiella pneumoniae carbapenemase, KPC）的菌株。