Gut microbiome in colitis male and female mice

The chronic colitis model of male and female mice was established by DSS (dextran sulfate sodium).The diversity and differences of gut microbiome in feces of ulcerative colitis and normal mice were identified by 16S rRNA high-throughput sequencing technology. The existing gene database was used to estimate the functional gene composition of the intestinal flora and the functional differences between the four groups.

本数据集通过葡聚糖硫酸钠（DSS，dextran sulfate sodium）构建雌雄小鼠慢性结肠炎模型；采用16S rRNA高通量测序技术，解析溃疡性结肠炎（ulcerative colitis）模型小鼠与正常小鼠粪便肠道菌群的多样性及组间差异；依托现有基因数据库，预测肠道菌群的功能基因组成，并分析四组样本间的功能差异。