CIL:48812, Mus musculus, MC57-Cerulean. In Cell Image Library
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https://library.ucsd.edu/dc/object/bb51269591
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To determine the origin (local vs. circulating) of tumor associated fibroblasts, a parabiotic pair of mice was created where only one mouse expressed EGFP under the control of the type I collagen alpha-1 promoter (COL-EGFP), and the other mouse expressed DsRed ubiquitously. On each mouse of the parabiotic pair, MC57-Cerulean cancer cells were injected on the distal flank. This folder contains images from the tumor grown in the COL-EGFP mouse, freshly explanted and analyzed ex vivo. The blue channel shows cancer cells, the red channel shows DsRed cells, the green channel shows COL-EGFP+ fibroblasts.
Image name: 120513 Parabiot Rag MC57 COLEGFP tumor flank.lif - 4
Project: 20389
为明确肿瘤相关成纤维细胞（tumor associated fibroblasts）的来源（局部来源与循环来源），研究人员构建了一对共生配对小鼠：其中一只在I型胶原α1启动子调控下表达EGFP（记为COL-EGFP小鼠），另一只泛在表达DsRed。在每只共生配对小鼠的远端侧腹部位，均接种了MC57-Cerulean癌细胞。本文件夹包含取自COL-EGFP小鼠体内生长的肿瘤的成像数据，该肿瘤已被新鲜摘除并进行离体分析。其中，蓝色通道显示癌细胞，红色通道显示DsRed标记细胞，绿色通道显示COL-EGFP阳性成纤维细胞。
图像文件名：120513 Parabiot Rag MC57 COLEGFP tumor flank.lif - 4
项目编号：20389
提供机构：
UC San Diego Library Digital Collections
创建时间：
2021-04-15
