Echinocandin microevolution causes resistance in Candida parapsilosis

Fungal diseases emerging worldwide. Among Candida species antifungal resistance becoming a large danger. C. parapsilosis is one of the causative agents of candidiasis and this species has the highest MIC value to echinocandins, however echinocandin resistant clinical isolates are extremely rare. To reveal the mechanisms how C. parapsilosis can adapt to echinocandins, we directly selected C. parapsilosis to resist against each echinocandins and we performed whole genome sequencing on this strain.

全球范围内不断涌现的真菌病害。在念珠菌（Candida）属中，抗真菌耐药性已成为重大威胁。近平滑念珠菌（C. parapsilosis）是念珠菌病（candidiasis）的致病菌之一，该菌种对棘白菌素（echinocandins）的最低抑菌浓度（MIC）值最高，但棘白菌素耐药的临床分离株极为罕见。为揭示近平滑念珠菌适应棘白菌素的分子机制，我们直接筛选出对各型棘白菌素耐药的近平滑念珠菌菌株，并对该耐药菌株开展了全基因组测序（whole genome sequencing）。