Thrombopoietin (TPO) protects against heart damage induced by doxorubicin and infarction in rat models. Rattus norvegicus

In order to examine the mechanism of TPO on cardiac protection against DOX damage, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to delineate the TPO cardioprotective mechanism against DOX-induced cardiomyopathy Overall design: Dox and TPO induced gene expressions in rat heart were measured at day 6. Two biological replicates were performed for each treatment group.

为厘清血小板生成素（Thrombopoietin, TPO）对抗阿霉素（Doxorubicin, DOX）诱导心脏损伤的保护机制，本研究采用全基因组微阵列表达谱作为筛选平台，以鉴定可阐明TPO抗阿霉素心肌病保护机制的潜在相关基因。
实验整体设计：于第6天检测大鼠心脏中DOX与TPO诱导的基因表达水平，每个处理组均设置2次生物学重复。