MiR-21 is targeted by STAT5 but dispensable for mammary gland development. Mus musculus

In this study we identifies miR-21 to by under cytokine control through the transcription factor STAT5 and while miR-21 is differentially expressed during mammary gland development, miR-21 is dispensable for mammary development and lactation. Overall design: We refer to wild-type mice (+/+) as WT and to mice lacking the mir-21 (-/-) as KO mice.

本研究证实，微小RNA-21（miR-21）受细胞因子调控，且该调控依赖转录因子STAT5（信号转导与转录激活因子5）；尽管miR-21在乳腺发育过程中呈差异表达，但它对于乳腺发育与泌乳并非必需。
实验整体设计：本研究将基因型为+/+的野生型小鼠记为WT，将mir-21基因敲除小鼠（基因型为-/-）记为KO小鼠。