Fuelling the Fight from the Gut: Short-Chain Fatty Acids and Dexamethasone Synergise to Suppress Gastric Cancer Cells

Short-chain fatty acids (SCFAs) are microbial metabolites, also known as postbiotics, produced by the gut microbiotame, playing essential rolesessential in maintaining gut health and exerting potential anticancer effects. This study investigates the antiproliferative effects of short-chain fatty acids (SCFAs) salts—magnesium acetate (A), sodium propionate (P), and sodium butyrate (B)—and their combinations with dexamethasone (Dex) in AGS gastric adenocarcinoma cells.

短链脂肪酸（Short-chain fatty acids，SCFAs）是肠道菌群产生的微生物代谢产物，亦被称为后生元（postbiotics），在维持肠道健康中发挥关键作用，并具备潜在抗癌活性。本研究探究了短链脂肪酸盐类——乙酸镁（A）、丙酸钠（P）与丁酸钠（B）——及其与地塞米松（Dexamethasone，Dex）联合使用时，对AGS胃腺癌细胞的抗增殖作用。