Fecal Dysbacteriosis in Chinese Elderly Patients with Schizophrenia

Schizophrenia (SZ) is a severe neuropsychiatric disorder, and its etiology and pathogenesis remain largely unknown. Mounting preclinical and clinical evidence suggest that the gut microbiome is a vital player in SZ. However, the gut microbiota characteristics as well as its host response in elderly SZ patients are not well understood.

精神分裂症（Schizophrenia, SZ）是一种严重的神经精神疾病，其病因与发病机制迄今仍未完全明确。日益增多的临床前及临床研究证据表明，肠道微生物组（gut microbiome）在精神分裂症的发生发展中发挥关键作用。然而，目前针对老年精神分裂症患者的肠道菌群（gut microbiota）特征及其宿主应答的相关认知仍有待深入阐明。