Supplementary Material for: Effect of Traditional Chinese Medicine on Psoriasis Vulgaris: A Meta Analysis and Systematic Review

Background: Psoriasis is a chronic, inflammatory autoimmune skin disease that affects 2%–3% of the world’s population. Lesions are mainly found on the limbs, trunk, and scalp, but may also affect other parts of the body, and the cause is not yet known. The chronic and relapsing nature of psoriasis makes it one of the most complex and important diseases in current dermatology research. Methods: The search was conducted using PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet, Wanfang Data, VIP journals database, and Chinese biomedical literature database (CBM). The retrieval time limit was from the establishment of the database to January 2021. The quality of the selected literature were evaluated, and ReView Manager 5.3 was used for Meta-analysis after randomized controlled trials were filtered. Results: Finally, 16 randomized controlled trials involving 1967 patients were included. The total effective rate (OR =3.68,95% CI[2.73,4.95], P<0.00001), cure rate (OR =2.01, 95% CI[1.62,2.49]c, P <0.00001), and PASI score (OR =-1.83, 95% CI[-2.39, -1.26], P <0.00001) of the traditional Chinese medicine (TCM) were superior than the Diyin tablet.. Conclusion: In the treatment of psoriasis, traditional Chinese medicine (TCM) shows higher efficacy than the Diyin tablet. However, due to the limitations of the included literature, we still need more double-blind, placebo-controlled trials with large samples and multiple centers to provide high-quality clinical evidence.

背景：银屑病（Psoriasis）是一种慢性炎症性自身免疫性皮肤病，全球约2%~3%的人口受其影响。皮损主要分布于四肢、躯干及头皮，亦可累及身体其他部位，目前其病因尚未明确。银屑病具有慢性、复发性的特征，使其成为当前皮肤病学研究中最为复杂且重要的疾病之一。方法：本研究检索了PubMed、Embase、Cochrane图书馆、Web of Science、中国知网（China National Knowledge Internet）、万方数据、维普期刊数据库及中国生物医学文献数据库（Chinese Biomedical Literature Database, CBM），检索时限为各数据库建库至2021年1月。对纳入的文献进行质量评价，筛选出随机对照试验后，采用ReView Manager 5.3软件开展Meta分析。结果：最终纳入16项随机对照试验，共涉及1967例患者。中医药（traditional Chinese medicine, TCM）治疗的总有效率（优势比OR=3.68，95%置信区间CI[2.73,4.95]，P<0.00001）、治愈率（OR=2.01，95%CI[1.62,2.49]，P<0.00001）及PASI评分（Psoriasis Area and Severity Index）（OR=-1.83，95%CI[-2.39,-1.26]，P<0.00001）均优于迪银片（Diyin tablet）。结论：在银屑病的治疗中，中医药的临床疗效优于迪银片。但受纳入文献的局限性影响，仍需开展更多大样本、多中心的双盲安慰剂对照试验，以提供高质量的临床证据。