Data source of Microphysiological engineering of the capillary interface of substantia nigra dopaminergic neurons to study vascular alterations in Parkinson’s Disease

Parkinson’s disease involves not only α-synuclein pathology but also significant vascular dysfunction that traditional models fail to capture. Using organ-on-a-chip technology and vasculogenic self-assembly, we created a midbrain model that mimics the capillary interface of dopaminergic neurons and blood vessel networks. When exposed to PD-associated α-synuclein fibrils, the system reproduced key disease features, including protein aggregation, inflammation, neurodegeneration, and progressive vascular impairment. This platform provides a powerful tool for studying how neuronal and vascular pathology interact in PD and for developing therapies that address both the neuronal and vascular components of PD pathology.

帕金森病（Parkinson’s disease）不仅伴随α-突触核蛋白病理（α-synuclein pathology），还存在显著的血管功能障碍，而传统模型无法捕捉此类病理特征。本研究借助器官芯片（organ-on-a-chip）技术与血管生成性自组装手段，构建了可模拟多巴胺能神经元与血管网络毛细血管界面的中脑模型。当该模型暴露于帕金森病相关α-突触核蛋白原纤维时，体系复现了疾病的关键特征，包括蛋白质聚集、炎症反应、神经退行性变以及进行性血管损伤。该平台为探究帕金森病中神经元与血管病理的相互作用机制，以及开发同时靶向帕金森病病理中神经元与血管组分的治疗方案，提供了强有力的研究工具。